No fewer than seven persons have been confirmed dead after a UPS wide-body cargo plane crashed in the United States on Tuesday, November 4, 2025.
Officials disclosed that the plane crashed moments after takeoff from the international airport in Louisville, Kentucky, killing seven, including all three aboard, and injuring 11 on the ground.
Flames from the crash, shortly before sundown, ignited a string of fires in an industrial corridor adjacent to the airport, forcing authorities to halt flight operations through the night.
The Louisville airport, which is home to UPS Worldport – a global hub for the shipping company’s air cargo operations and its largest package-handling facility worldwide – was expected to reopen on Wednesday morning.
Two runways were strewn with debris from the crash, according to Reuters.
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In a Tuesday night service alert, UPS said delivery schedules for airborne and international packages “may be affected” by the disruption.
“Contingency plans are in place to help ensure that shipments arrive at their final destinations as quickly as conditions permit,” it added.
The triple-engine plane was fueled for an 8-1/2-hour flight to Honolulu. It had a crew of three, UPS aid. None survived, officials said.
Louisville Mayor Craig Greenberg told reporters at a late-night news briefing that four deaths were confirmed on the ground, with 11 injured people taken to hospitals.
Separately, Kentucky Governor Andy Beshear said the death toll was at least seven and expected to rise, adding that some survivors suffered “very significant” injuries.
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