Carabao Cup holders Newcastle will host Fulham in the quarter-finals, while Arsenal will face fellow Londoners Crystal Palace.
Newcastle – who beat Liverpool in the March final to win their first trophy in nearly 56 years – eased past Tottenham 2-0 in their fourth round tie, while Fulham needed penalties to see off League One side Wycombe.
Arsenal beat Brighton 2-0 on Wednesday night, while Crystal Palace thrashed Liverpool 3-0 at Anfield.
The meeting between the Gunners and the Eagles is a replay of last year’s Carabao Cup quarter-final, where Arsenal came from behind to win 3-2 at the Emirates.
League One side Cardiff have been rewarded with a home game against Chelsea, after they beat fellow Welsh side Wrexham 2-1 on Tuesday evening.
The Blues endured a thriller against Wolves, winning 4-3 in a dramatic encounter that saw Liam Delap sent off.
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It will be a reunion for Brian Barry-Murphy and Enzo Maresca. The Cardiff boss worked under the Italian at Manchester City and replaced him as their B team coach.
Brentford travel to Manchester City to complete the ties for the final eight sides.
The Bees were arguably the biggest winners of the fourth round, beating Grimsby 5-0, while City came from behind to see off Swansea with a 3-1 win.
The quarter-final matches will be played on December 15.
Carabao Cup quarter-final draw in full:
Arsenal vs Crystal Palace
Cardiff vs Chelsea
Man City vs Brentford
Newcastle vs Fulham
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