Liverpool face in-form Aston Villa as the Premier League champions look to arrest their remarkable collapse on Saturday, while third-placed Tottenham host London rivals Chelsea.
Arsenal will also aim to surge further clear in the Premier League title race as the Gunners hold a four-point lead over Bournemouth, who travel to Manchester City, before their trip to Burnley.
Tottenham are only five points off the top but are aiming to end a three-game winless run at home when they host Chelsea.
Liverpool boss Arne Slot badly needs his star names to get back on track after being dumped out the Carabao Cup by Crystal Palace on Wednesday to compound a miserable run for the Premier League champions.
Slot made his priorities clear by making 10 changes as Palace cruised to a 3-0 win at Anfield against a youthful Liverpool selection.
The Dutchman said he could not risk any more injuries to his key players with the visit of Villa quickly followed by clashes against Real Madrid and Manchester City.
Five games into the Premier League campaign, Liverpool led Villa by 12 points. Four matches later they meet separated only by goal difference.
Villa have overcome their difficult start with four consecutive wins, including notable scalps against Tottenham and City, to surge back into contention for the Champions League places.
At the same time, Liverpool’s title defence has imploded.
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The Reds have not kept a clean sheet for 10 games as Slot struggles to find the right balance to a side disrupted by a huge squad turnover during the transfer window.
Liverpool spent a Premier League record near £450 million, but crucially lost more players than they recruited, with Trent Alexander-Arnold and Luis Diaz particularly missed.
Below are Premier League fixtures scheduled for the weekend:
Saturday
Brighton v Leeds
Burnley v Arsenal
Crystal Palace v Brentford
Fulham v Wolves
Nottingham Forest v Man United
Tottenham v Chelsea
Liverpool v Aston Villa
Sunday
West Ham v Newcastle
Man City v Bournemouth
Monday
Sunderland v Everton
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