Title-chasing Manchester City face leaders Arsenal in a seismic showdown at the top of the Premier League on Sunday.
Troubled Chelsea will face Manchester United in the race for Champions League qualification at Stamford Bridge, while Liverpool are also in search of a morale boost in the Merseyside derby.
Arsenal travel to the Etihad Stadium on Sunday nursing a six-point lead over second-placed City as they target a first English title since 2004.
The Gunners have spluttered in recent weeks, losing the Carabao Cup final against City, suffering a shock FA Cup quarter-final defeat against second-tier Southampton, and crashing to a damaging loss against Bournemouth in the Premier League.
Arsenal’s progress to the Champions League semi-finals came with an asterisk after they laboured to a nervy goalless draw that secured a 1-0 aggregate victory against Sporting Lisbon on Wednesday.
Arsenal have won just one of their last five matches in all competitions, while City are approaching top gear, having beaten Arsenal, Liverpool, and Chelsea in their last three games.
Rocked by a miserable run of just one win in their last seven league games, Chelsea are on the brink of falling out of the battle for Champions League places.
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Chelsea have no margin for error in Saturday’s game against third-placed Manchester United at Stamford Bridge.
The Blues are seven points behind United, who lost to Leeds in their last match, and four adrift of fifth-placed Liverpool with six games to play.
A defeat against United would put Chelsea’s Champions League hopes in grave danger, increasing the pressure on boss Liam Rosenior after his team were booed off following last weekend’s 3-0 loss to Manchester City.
Below are the Premier League fixtures slated for the weekend:
Saturday
Brentford v Fulham
Leeds v Wolves
Newcastle v Bournemouth
Tottenham v Brighton
Chelsea v Manchester United
Sunday
Aston Villa v Sunderland
Everton v Liverpool
Nottingham Forest v Burnley
Manchester City v Arsenal
Monday
Crystal Palace v West Ham
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